… Cytokines targeted by agents in active clinical trials of SLE are indicated in red. Potential
cytokine targets for SLE therapy … In the following section, we discuss anticytokine therapies for …

… therapeutics targeting cytokines. Why is this the case? As in RA, a large number of cytokines
are upregulated, but therapeutics … in asthma (21), nor did therapeutics blocking IL-4 (22). …

… of therapies targeting these cytokines and their receptors. Herein, we briefly describe the
properties and interactions of IL-17 and IL-23 (forming the IL-23/-17 axis) and present the main …

… Cytokines are therefore attractive therapeutic targets in these conditions. Anticytokine therapy
for … Finally, we report on the current state of trials for newer therapeutic targets, focusing …

… Finally, we discuss the promises and challenges of cytokine and chemokine targeting in …
from targeted cytokine therapeutics [153]. Third, the need for chronic administration of cytokine …

… Biological therapies targeting cytokines, T cells, or B cells have improved outcomes of
inflammatory diseases. However, many issues remain open: What is the best target? How …

… these cytokines in the liver are briefly summarized. Several cytokines have great therapeutic
potential, and some are currently being tested as therapeutic targets in clinical trials for the …

… The actions of individual pro- and anti-inflammatory cytokines are described in more detail …
of cytokine actions in recent years, a number of therapeutic strategies targeting cytokines and …

… targets. The pharmaceutical industry shows little interest in developing biological therapies
primarily for SS; therefore we will focus on cytokines that could be targeted with biological …

… Nevertheless, cytokine inhibition is … of cytokines on atherosclerosis, myocardial infarction,
and stroke. Then, we discuss evidence from clinical trials specifically targeting cytokines and …